Chinese Journal of Organic Chemistry >
Palladium-Catalyzed C-H Direct Arylation of Uracils and Caffeines with Arenes Using Molecular Oxygen as the Sole Oxidant
Received date: 2018-02-04
Revised date: 2018-03-25
Online published: 2018-04-13
Supported by
Project supported by the National Natural Science Foundation of China (No. 6152010615), the Natural Science Foundation of Fujian Province (No. 2017J01572), the Foundation of Fujian Educational Committee (No. JZ160424), the Fujian Province University Fund for New Century Excellent Talents, and Undergraduate Training Program for Innovation and Entrepreneurship (No. 201710394061).
Palladium-catalyzed cross-dehydrogenative coupling of uracil or caffeine with unactivated arenes has been developed. The approach was characterized by using atmospheric pressure of molecular oxygen as the sole oxidant. Functional groups such as halo, ester, nitro, nitrile and ether are well-tolerated under the reaction conditions. This novel strategy provides a straightforward, facile and economical route to C6-aryl uracil derivatives or C8-aryl caffeine derivatives.
Pan Guoshuai , Wu Kongchuan , Deng Zeying , Zhang Xinyu , Zhang Xiaofeng , Lin Shen , Huang Qiufeng . Palladium-Catalyzed C-H Direct Arylation of Uracils and Caffeines with Arenes Using Molecular Oxygen as the Sole Oxidant[J]. Chinese Journal of Organic Chemistry, 2018 , 38(8) : 2076 -2084 . DOI: 10.6023/cjoc201802008
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