Chinese Journal of Organic Chemistry >
Enantioselective Synthesis of Core Structures of Hydramicromelins A, B and C
Received date: 2018-02-09
Revised date: 2018-03-28
Online published: 2018-04-27
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21372205, 21302175) and the Basic Research Project of Science and Technology Department of Henan Province (No. 132300410028).
Hydramicromelins A~C are coumarin compounds with unique chemical structure and biological activity. With[2,3]-Meisenheimer rearrangemen as a key reaction which has been developed in our laboratory, the core structures of Hydramicromelin A, B and C were synthesized from L-phenylglycine. The route included Wittig reaction,[2,3]-Meisenheimer rearrangement, epoxidation and dihydroxylation reaction, and it was high-yield and high-enantioselectivity.
Sun Moran , Dai Lei , Yang Hua , Liu Hongmin , Yu Dequan . Enantioselective Synthesis of Core Structures of Hydramicromelins A, B and C[J]. Chinese Journal of Organic Chemistry, 2018 , 38(9) : 2443 -2449 . DOI: 10.6023/cjoc201802017
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