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Chinese Journal of Organic Chemistry >

2018 , Vol. 38 >Issue 10: 2784 - 2790

DOI: https://doi.org/10.6023/cjoc201801040

Notes

Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole

  • Cui Penglei ,
  • Liu Na ,
  • Chen Hua ,
  • Li Xiaoliu
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  • a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b College of Science, Agricultural University of Hebei, Baoding 071001

Received date: 2018-01-27

  Revised date: 2018-03-19

  Online published: 2018-06-01

Supported by

Project supported by the Science and Technology Fund of Agricultural University of Hebei (No. LG20150503)

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Abstract

A series of unreported thiouracil derivatives 7 containing a benzothiazole moiety were synthesized by the reaction of 4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (6) with N-(benzo[d]thiazol-2-yl)-4-(chloromethyl)-benzamide (5), which was prepared from the amidation of 2-aminobenzothiazole and 4-(chloromethyl)benzoyl chloride. The newly synthesized compounds 7 were characterized by IR, MS, NMR, and element analysis. All the compounds were evaluated for their antibacterial activities against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis. The results of the 24-hour antibacterial test showed that some compounds had good inhibitory activities against the three tested strains.

Key words： thiouracil; benzothiazole; antibacterial activity

Cite this article

Cui Penglei , Liu Na , Chen Hua , Li Xiaoliu . Synthesis and Antibacterial Activity Evaluation of the Thiouracil Derivatives Containing Benzothiazole[J]. Chinese Journal of Organic Chemistry, 2018 , 38(10) : 2784 -2790 . DOI: 10.6023/cjoc201801040

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