Chinese Journal of Organic Chemistry >
Chemical (Semi-) Synthesis and Applications of Lysine Post-Translationally Modified Proteins
Received date: 2018-04-28
Revised date: 2018-05-19
Online published: 2018-06-07
Supported by
Project supported by the National Natural Science Foundation of China (No. U1732161), the Science and Technological Fund of Anhui Province for Outstanding Youth (No. 1808085J04) and the Innovative Program Development Foundation of Hefei Center Physical Science and Technology (No. 2017FXCX002).
The study of native proteins with post-translational modifications (PTMs) is one of the main fields of epigenetics. The discovery of novel PTM models and their vital regulatory role for chromatin structure and gene transcription have been one of the current research focuses drawing attention of biologists especially in recent years. However, we still lack efficient strategies for the preparation of sufficient amount of native proteins with certain PTMs. The currently existing chemical biology methods are reviewed, and their advantages and disadvantages are compared, including bioorthogonal reaction technique, non-canonical amino acid incorporation, etc. Furthermore, the draft will mainly focus on the application of bioorthogonal reactions on unnatural functional groups for the incorporation of lysine PTMs.
Wang Zhipeng , Li Man , Li Hui , Liu Zhihua , Li Ying , Zheng Ji-Shen . Chemical (Semi-) Synthesis and Applications of Lysine Post-Translationally Modified Proteins[J]. Chinese Journal of Organic Chemistry, 2018 , 38(9) : 2400 -2411 . DOI: 10.6023/cjoc201804046
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