Chinese Journal of Organic Chemistry >
Synthesis and Antimicrobial Activity of 2-Substituted-phenyl-3-(N, N-dimethylformamido)-4-methyl-1,5-benzothiazepine
Received date: 2018-04-16
Revised date: 2018-05-31
Online published: 2018-06-22
Supported by
Project supported by the Natural Science Foundation of Hebei Province (No. B2017205100).
By introducing N,N-dimethylformamido into 1,5-benzothiazepine, 6 compounds of 2-substituted-phenyl-3-(N,N-dimethylformamido)-4-methyl-1,5-benzothiazepine 3a～3f were designed and synthesized, Studies on the synthesis conditions of 3a～3f revealed that 3a～3f were dynamic control products. 3a～3f had obvious inhibitory effect on fungi and bacteria especially for Cryptococcus neoformans and Escherichia coli.
Xu Tongxiu , Wang Yan , Tian Keqing , Wang Ranran , Yan Jingyi , Zhang Ping . Synthesis and Antimicrobial Activity of 2-Substituted-phenyl-3-(N, N-dimethylformamido)-4-methyl-1,5-benzothiazepine[J]. Chinese Journal of Organic Chemistry, 2018 , 38(10) : 2731 -2735 . DOI: 10.6023/cjoc201804029
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