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Chinese Journal of Organic Chemistry >

2018 , Vol. 38 >Issue 11: 3123 - 3126

DOI: https://doi.org/10.6023/cjoc201804037

Notes

CBr4-Promoted Efficient Synthesis of 2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitriles

  • Wang Xiang ,
  • Chen Ping ,
  • Zhi Sanjun ,
  • Hu Huayou ,
  • Kan Yuhe
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  • Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huai'an 223300

Received date: 2018-04-18

  Revised date: 2018-06-13

  Online published: 2018-06-29

Supported by

Project supported by the National Natural Science Foundation of China (No. 51403073), the Department of Education of Jiangsu Province (No. 16KJB150006) and the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials (No. JSKC15145).

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Abstract

2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitrile derivatives not only exhibit a variety of important biological activities, but also are important intermediates in organic synthesis. The CBr4-promoted reaction of aromatic aldehydes with 2-(1H-benzo[d] imidazol-2-yl) acetonitrile to obtain 2-(1H-benzo[d] imidazol-2-yl)-3-arylacrylonitriles was developed. Structurally diverse 2-(1H-benzo[d] imidazol-2-yl)-3-arylacrylonitriles were obtained in moderate to good yields (74%~96%) under mild conditions. This method has the advantages of operational simplicity and wide substrate scope.

Key words： benzimidazol; carbon tetrabromide; acrylonitrile; Knoevenagel condensation

Cite this article

Wang Xiang , Chen Ping , Zhi Sanjun , Hu Huayou , Kan Yuhe . CBr4-Promoted Efficient Synthesis of 2-(1H-Benzo[d] imidazol-2-yl)-3-arylacrylonitriles[J]. Chinese Journal of Organic Chemistry, 2018 , 38(11) : 3123 -3126 . DOI: 10.6023/cjoc201804037

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