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Chinese Journal of Organic Chemistry >

2018 , Vol. 38 >Issue 11: 3009 - 3015

DOI: https://doi.org/10.6023/cjoc201806035

Articles

Aniline-Promoted Synthesis of Isobenzofuranone Derivatives

  • Yuan Shuo ,
  • Wang Sixi ,
  • Chen Jinjie ,
  • Zhao Longfei ,
  • Yu Bin ,
  • Liu Hongmin
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  • a School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001;
    b Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001;
    c Key Laboratory of Technology of Drug Preparation, Ministry of Education, Zhengzhou 450001;
    d Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou 510033

Received date: 2018-06-21

  Revised date: 2018-07-16

  Online published: 2018-07-24

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 81430085, 81773562, 81703326), the National Key Research Program of Proteins (No. 2016YFA0501800), the Scientific Program of Henan Province (No. 182102310123), the China Postdoctoral Science Foundation (No. 2018M630840), the Open Project of Guangdong Provincial Key Laboratory of New Drug Screening (No. GDKLNDS-2018OF006), the Key Research Program of Higher Education of Henan Province (No. 18B350009), and the Undergraduate Innovation and Entrepreneurship Training Program of Zhengzhou University (No. 201810459101).

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Abstract

Isobenzofuranone derivatives are widely found in nature and have shown diverse biological activities. In this work, the aniline-promoted synthesis of isobenzofuranone derivatives starting from 2-carboxybenzaldehyde and substituted acetophenones under mild reaction conditions is reported. This method has broad substrate scope, high yields, and is operationally convenient, and therefore could serve as an attractive strategy for practical synthesis of isobenzofuranone derivatives.

Key words： isobenzofuranone derivatives; aniline; cascade reactions

Cite this article

Yuan Shuo , Wang Sixi , Chen Jinjie , Zhao Longfei , Yu Bin , Liu Hongmin . Aniline-Promoted Synthesis of Isobenzofuranone Derivatives[J]. Chinese Journal of Organic Chemistry, 2018 , 38(11) : 3009 -3015 . DOI: 10.6023/cjoc201806035

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