Chinese Journal of Organic Chemistry >
Synthesis and Biological Activity of Azaclozodihypyrimidine and Pyrimidine Derivatives
Received date: 2018-04-11
Revised date: 2018-07-19
Online published: 2018-08-14
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21572044, 21372060, 21172051), Hebei Natural Science Foundation (No. B2016201031) and Program for Changjiang Scholars and Innovative Research Team in University (No. IRT-15R43), the Colleges and Universities Science Technology Research Project of Hebei Province (No. QN2017015).
A series of novel aryl-substituted imidazo[1,2-a]pyrimidine and triazolo[1,5-a] pyrimidine were synthesized by the tandem reaction of Knoevenagel and Atwal modified Biginelli, following by aromatization. Some of their cytotoxic activities against Hela and A549 cells and inhibition for apple tree canker were preliminarily evaluated.
Zhang Pingzhu , Wang Xiaofen , Zheng Xueyang , Lian Pingping , Wei Chao , Li Xiaoliu . Synthesis and Biological Activity of Azaclozodihypyrimidine and Pyrimidine Derivatives[J]. Chinese Journal of Organic Chemistry, 2018 , 38(12) : 3278 -3285 . DOI: 10.6023/cjoc201804020
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