Chinese Journal of Organic Chemistry >
Alanine Triazole Mn-Catalyzed Coupling/Aromatization of Quinone Methides
Received date: 2018-05-08
Revised date: 2018-07-18
Online published: 2018-08-14
Supported by
Project supported by the National Natural Science Foundation of China (No. 2176111), the Fundamental Research Funds for the Central Universities (No. JUSRP 51627B).
Alanine triazole Mn-catalyzed 1,6-conjugate coupling/aromatization of para-quinone methides was developed with good to high yields under mild conditions. This protocol provided an efficient and practical route to the synthetically interesting functionalized methines and their analogues. Preliminary mechanistic experiments revealed 1,6-conjugate addition of nucleophiles to para-quinone methides (p-QMs). The manganese was acted as the Lewis acid.
Key words: quinone methide; manganese; ligand; triazole
Hu Xinyu , Yang Bobin , Yao Wei , Wang Dawei . Alanine Triazole Mn-Catalyzed Coupling/Aromatization of Quinone Methides[J]. Chinese Journal of Organic Chemistry, 2018 , 38(12) : 3296 -3301 . DOI: 10.6023/cjoc201805019
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