Chinese Journal of Organic Chemistry >
Synthetic Biology Studies of Monoterpene Indole Alkaloids
Received date: 2018-06-01
Revised date: 2018-08-04
Online published: 2018-08-14
Supported by
Project supported by the Science and Technology Commission of Shanghai Municipality (Nos. 18ZR1447000, 15JC1400402).
Monoterpene indole alkaloids (MIAs) are a group of important specialized metabolites that exhibit a broad range of pharmacological activities. However, the contents of MIAs in natural plants are extremely low. It could be produced through advanced synthetic chemistry, but the production scale is very limited, and the further modification of the key scaffold is very difficult. With the full elucidation of MIAs biosynthetic pathway and deeper investigation of biotechnology in synthetic biology, the use of synthetic biology strategies combined with chemical semi-synthesis will be an important development trend for the synthesis of these compounds and their derivatives. Elucidation of MIAs biosynthetic pathway by characterizing involved genes is the prerequisite for synthetic biology. Strictosidine, which was formed by the combination of tryptamine and secologanin, is the key intermediate for MIAs biosynthesis. The discovery of biological parts and research advances of synthetic biology of MIAs based on the upstream biosynthetic pathway, the formation of strictosidine, and downstream biosynthetic pathway, production of divergent MIAs derived from strictosidine over the past three decades are described. This review could provide guidance for further elucidation of other MIAs and promotion of synthetic biology for producing MIAs.
Wu Shiwen , Yang Mengquan , Xiao Youli . Synthetic Biology Studies of Monoterpene Indole Alkaloids[J]. Chinese Journal of Organic Chemistry, 2018 , 38(9) : 2243 -2258 . DOI: 10.6023/cjoc201806001
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