Chinese Journal of Organic Chemistry >
Research on the Semi-synthesis of Pectolinarin from Scutellarin
Received date: 2018-07-27
Revised date: 2018-09-14
Online published: 2018-10-12
Supported by
Project supported by the National Natural Science Foundation of China (No. 81773576).
As the representative flavonoid and flavonoid glycoside of Chinese medicine Cirsium japonicum, pectolinarigenin and pectolinarin have important bioactivities. In this paper, the efficient semi-synthesis of pectolinarigenin had been achieved starting from commercially available scutellarin via a linear reaction sequence of 3 steps with the overall yield of 69.5%, wherein carboxyl esterification, selective hydroxy protecting, and glycosidic bond hydrolyzation were used. Afterwards, the chemical synthesis of pectolinarin had been accomplished by the glycosylation of pectolinarigenin and benzobromorutinose.
Key words： scutellarin; pectolinarigenin; pectolinarin; flavonoids; semi-synthesis
Yan Shiqiang , Xie Mingxian , Wang Yujie , Li Yingxia . Research on the Semi-synthesis of Pectolinarin from Scutellarin[J]. Chinese Journal of Organic Chemistry, 2019 , 39(2) : 412 -418 . DOI: 10.6023/cjoc201807051
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