Chinese Journal of Organic Chemistry >
Recent Advances in the Synthesis of CF3-Substituted Triazoles and Tetrazoles
Received date: 2018-08-07
Revised date: 2018-09-14
Online published: 2018-10-12
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21472137, 21532008, 21772142) and the National Basic Research Program of China (973 Program, No. 2014CB745100).
Trifluoromethylated triazoles and tetrazoles have emerged as increasingly important heterocycles in pharmaceuticals, agrochemicals, catalysis, and materials. As a consequence, great attention has been paid to the efficient synthesis of these valuable CF3-containing molecules. Herein, the advances in the past decade towards the synthesis of CF3-substituted triazoles and tetrazoles are summarized. The remarkable progress in the utilization of versatile CF3-functionalized building blocks including CF3-containing alkynes, CF3-containing carbonyl compounds, CF3-containing pyrones and trifluorodiazoethane (CF3CHN2) is demonstrated accordingly.
Zhang Faguang , Peng Xing , Ma Jun'an . Recent Advances in the Synthesis of CF3-Substituted Triazoles and Tetrazoles[J]. Chinese Journal of Organic Chemistry, 2019 , 39(1) : 109 -116 . DOI: 10.6023/cjoc201808007
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