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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 3: 867 - 872

DOI: https://doi.org/10.6023/cjoc201806029

Notes

Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives

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  • a School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114;
    b CAC Shanghai International Trading Co., Ltd., Shanghai 200335

Received date: 2018-06-19

  Revised date: 2018-09-05

  Online published: 2018-10-26

Supported by

Project supported by the Changsha Science and Technology Project (Nos. kq1801163, kq1801052) and the Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources (No. 2018KJY08).

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Abstract

In order to find lead compounds with high fungicidal activity, the phenyl moiety of pydiflumetofen was replaced by substituted 1-phenyl-3-hydroxylpyrazole moiety of pyraclostrobin according to the method of active substructure combination. 12 novel N-alkoxyl amides were synthesized and their structures were confirmed by 1H NMR, 13C NMR and HRMS. Preliminary fungicidal activity screening results showed that some analogues exhibited certain fungicidal activity against Phakopsora pachyrhizi, Pseudoperonospora cubensis or Erysiphe cichoracearum, compound 3a displayed 95% protective effect against Erysiphe cichoracearum at 100 mg/L.

Key words： pydiflumetofen; amide; pesticide; fungicidal activity

Cite this article

Huang Pengmian, Zhou Zhihui, Du Yonglei, Pang Huailin, Lü Liang . Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives[J]. Chinese Journal of Organic Chemistry, 2019 , 39(3) : 867 -872 . DOI: 10.6023/cjoc201806029

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