Chinese Journal of Organic Chemistry >
Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives
Received date: 2018-07-24
Revised date: 2018-10-22
Online published: 2018-11-26
Supported by
Project supported by the China Postdoctoral Science Foundation (No. 2016M601971).
A series of novel 4-arylamino pyrimidine derivatives were synthesized using substituted aniline as starting material via diazotization, Meerwein arylation, isothiocyanation, addition, methylation and cyclization. The preliminary results of insecticidal activities indicated that most of the compounds exhibited 100% insecticidal activitiy against Mythimna separata Walker at 500 mg/L. At 20 mg/L, N-(2-chloro-4-fluorophenyl) -2,6-dimethyl-5-(4-phenoxy-2-(trifluoromethyl) phenyl) -pyrimidin-4-amine (6h) exhibited 80% and 60% mortality against Mythimna separata Walker and Plutella xylostella Linnaeus, respectively.
Key words： 4-arylamino pyrimidine; pyrimidinamine; synthesis; insecticidal
Wu Ningjie , Cheng Long , Wang Jian , Yu Jiping , Xing Jiahua , Xu Tianming , Wei Youchang . Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives[J]. Chinese Journal of Organic Chemistry, 2019 , 39(3) : 852 -860 . DOI: 10.6023/cjoc201807044
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