Notes

Three New Polycyclic Polyprenylated Acylphloroglucinols from Hypericum lagarocladum

  • Wang Kou ,
  • Wang Yun ,
  • Wang Ziming ,
  • Ding Linfen ,
  • Hu Jianlin ,
  • Chen Ji
Expand
  • a School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500;
    b Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming 650500

Received date: 2018-07-31

  Revised date: 2018-10-19

  Online published: 2018-11-26

Supported by

Project supported by the National Natural Science Foundation of China (No. 20402072), the Program of One Hundred Young and Middle-aged Academic and Technical Talents of Kunming Medical University (No. 60117190410), and the Key Laboratory Training Program in Yunnan Province (No. 2017DG006).

Abstract

Three new polycyclic polyprenylated acylphloroglucinols (PPAPs) were isolated from Hypericum lagarocladum by means of various chromatographic techniques. Their structures were identified as hyperlagarin A (1), hyperlagarin B (2), and hyperlagarin C (3) on the basis of extensive spectroscopic analyses, including HRMS, 1D-and 2D-NMR.

Cite this article

Wang Kou , Wang Yun , Wang Ziming , Ding Linfen , Hu Jianlin , Chen Ji . Three New Polycyclic Polyprenylated Acylphloroglucinols from Hypericum lagarocladum[J]. Chinese Journal of Organic Chemistry, 2019 , 39(3) : 848 -851 . DOI: 10.6023/cjoc201807059

References

[1] Yang, X. W.; Grossman, R. B.; Xu, G. Chem. Rev. 2018, 118, 3508.
[2] Leuner, K.; Li, W.; Amaral, M. D.; Rudolph, S.; Calfa, G.; Schuwald, A. M.; Harteneck, C.; Inoue, T.; Pozzo-Miller, L. Hippocampus 2013, 23, 40.
[3] Gibon, J.; Deloulme, J.-C.; Chevallier, T.; Ladeveze, E.; Abrous, D. N.; Bouron, A. Int. J. Neuropsychopharmacol. 2013, 16, 189.
[4] Sell, T. S.; Belkacemi, T.; Flockerzi, V.; Beck, A. Sci. Rep. 2015, 4, 7500.
[5] Silva, S. M.; Martinho, A.; Moreno, I.; Silvestre, S.; Granadeiro, L. B.; Alves, G.; Duarte, A. P.; Domingues, F.; Gallardo, E. Life Sci. 2016, 144, 30.
[6] Ting, C. P.; Maimone, T. J. J. Am. Chem. Soc. 2015, 137, 10516.
[7] Bellavance, G.; Barriault, L. Angew. Chem., Int. Ed. 2014, 53, 6701.
[8] Biber, N.; Mows, K.; Plietker, B. Nat. Chem. 2011, 3, 938.
[9] Editoria Committee of Flora Reipublicae Popularis Sinicae Flora Reipublicae Popularis Sinicae, Vol. 50(2), Science Press, Beijing, 1990, p. 19(in Chinese). (中国科学院中国植物志编委会, 中国植物志, 50卷(第二分册), 科学出版社, 1990, p. 19.)
[10] Xin, W. B.; Man, X. H.; Zheng, C. J.; Jia, M.; Jiang, Y. P.; Zhao, X. X.; Jin, G. L.; Mao, Z. J.; Huang, H. Q.; Qin, L. P. Fitoterapia 2012, 83, 1540.
[11] Hashida, W.; Tanaka, N.; Kashiwada, Y.; Sekiya, M.; Ikeshiro, Y.; Takaishi, Y. Phytochemistry 2008, 69, 2225.
[12] Zhu, H. C.; Chen, C. M.; Liu, J. J.; Sun, B.; Wei, G. Z.; Li, Y.; Zhang, J. W.; Yao, G. M.; Luo, Z. W.; Xue, Y. B.; Zhang Y. H. Phytochemistry 2015, 115, 222.
[13] Chen, X. Q.; Li, Y.; Li, K. Z.; Peng, L. Y.; He, J.; Wang, K.; Pan, Z. H.; Cheng, X.; Li, M. M.; Zhao, Q. S.; Xu, G. Chem. Pharm. Bull. 2011, 59, 1250.
[14] Zhang, J. J.; Yang, X. W.; Ma, J. Z.; Liu, X.; Yang, L. X.; Yang, S. C.; Xu, G. Nat. Prod. Bioprospect. 2014, 4, 73.

Outlines

/