Chinese Journal of Organic Chemistry >
Isosteroidal Alkaloids from Fritillaria karelinii
Received date: 2018-09-12
Revised date: 2018-10-19
Online published: 2018-11-26
Supported by
Project supported by the National Natural Science Foundation of China and the People's Government of Xinjiang Uygur Autonomous Region (NSFC-Xinjiang Joint Fund, No. U1403201).
Three new isosteroidal alkaloids, karelinine (1), 5-epikarelinine (2), and 27-epiebeienine (3), were isolated from the bulbs of Fritillaria karelinii by column chromatography and semipreparative HPLC (high performance liquid chro-matography), together with three known ones, ebeienine (4), persicanidine B (5), and heilonine (6). Their structures were identified by MS, 1D/2D NMR, and single-crystal X-ray diffraction. Compound 1 is a 5β-jervine isosteroidal alkaloid featuring a cis-fused A/B ring moiety, rarely found in the Fritillaria genus. Compounds 1 and 2 also represent the first jervine alkaloids with a 15 α-hydroxy group from this genus.
Huang Jinchang, Lei Chun, Aisa Haji Akber, Yu Meihua, Yili Abulimiti, Hou Aijun . Isosteroidal Alkaloids from Fritillaria karelinii[J]. Chinese Journal of Organic Chemistry, 2019 , 39(3) : 842 -847 . DOI: 10.6023/cjoc201809019
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