Chinese Journal of Organic Chemistry >
Research Progress in Prodrugs of Acyclic Nucleoside Phosphonates Antiviral Agents
Received date: 2018-08-16
Revised date: 2018-10-15
Online published: 2018-11-30
Supported by
Project supported by the Natural Science Foundation of Hebei Province (No.H2018307055) and the Technology Innovation Foundation of Hebei Normal University (No.L2017K06).
More and more attention has been focused on acyclic nucleoside phosphonates (ANPs) antiviral agents which were wildly used in clinical therapy. However, poor oral bioavailability and high toxicity directly related to the phosphonate charge were serious and unnegligible especially for the treatment of chronic diseases such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Preparing appropriate forms of prodrug could enhance the oral bioavailability and reduce the toxicity because of the smooth absorption of prodrugs and the release of active drug only at the target. This review summarizes some recent progress in prodrugs of ANPs antiviral agents based on the structures of tenofovir, adefovir and cidofovir.
Gao Mengyuana , Liu Hongtaob , Lian Yufeib , Gao Xinfenga , Geng Yunhea , Li Wenyan . Research Progress in Prodrugs of Acyclic Nucleoside Phosphonates Antiviral Agents[J]. Chinese Journal of Organic Chemistry, 2019 , 39(4) : 974 -981 . DOI: 10.6023/cjoc201808018
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