Chinese Journal of Organic Chemistry >
Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)2
Received date: 2018-08-31
Revised date: 2018-10-25
Online published: 2018-12-05
Supported by
Project supported by the National Natural Science Foundation of China (No. 21402067), the Natural Science Foundation of Jiangsu Province (No. BK20170569) and the Natural Science Fund for Colleges and Universities in Jiangsu Province (No. 17KJB150013).
Herein, a nucleophilic fluorination reaction to construct fluorine-containing β-ketoesters and β-ketoamides is reported. The reaction uses PhI(OAc)2 as oxidant and 3HF·Et3N as fluorinating reagent. It can effectively build a series of fluorochemical compounds containing quaternary carbon center under room temperature reaction conditions for 30 min. Compared with the traditional electrophilic fluorination reaction, this method has the advantages of no metal participation, short reaction time, simple reaction conditions and high reaction yield.
Wu Wensheng , Yuan Hang , Huang Gaokui , Jiang Chunhui , Lu Hongfei . Fluorination of β-Ketoesters and β-Ketoamides Based on PhI(OAc)2[J]. Chinese Journal of Organic Chemistry, 2019 , 39(1) : 137 -143 . DOI: 10.6023/cjoc201808047
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