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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 4: 1023 - 1028

DOI: https://doi.org/10.6023/cjoc201809028

Articles

A Novel Schiff-Base Fluorescent Probe for Cr3+ and Its Bioimaging in Cells

  • Chang Yongxina ,
  • Li Baia ,
  • Gao Yunfana ,
  • Xu Kuoxi
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  • a Institute of Functional Organic Molecular Engineering, Engineering Laboratory for Flame Retardant and Functional Materials of Henan Province, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004;
    b Henan University Mingsheng College, Kaifeng, 475004

Received date: 2018-09-21

  Revised date: 2018-10-29

  Online published: 2018-12-07

Supported by

Project supported by the National Natural Science Foundation of China (No.U1404207).

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Abstract

Trivalent chromium (Cr3+) plays an important role in the metabolismof fats, nucleic acids, carbohydrates and proteins. Moreover, Cr3+ is considered to be a carcinogen and is extremely harmful to humans. Therefore, Cr3+ fluorescent probe L was synthesized by reaction of 8-hydroxyquinolinaldehyde with thiocarbazone. The probe L showed high selectivity towards Cr3+ ion through the color of solution changed from colorless to yellow for naked-eye detection and significant fluorescence intensity enhanced in CH3CN/H2O (V:V=1:2, Tris buffer 50 mmol/L, pH=7.3) solution. The 1:1 binding stoichiometry between probe and Cr3+ was determined from Job's plot, fluorescence titration, ESI-MS and density functional theory (DFT) calculations. The association constant (Ka) and the detection limit for Cr3+ were found to be to be 1.00×105 and 2.85×10-7 mol/L, respectively. Moreover, bioimaging experiments showed that L could sense Cr3+ ion in living cells with a fluorescence enhancement signal.

Key words： Cr3+; fluorescent probe; DFT; bioimaging

Cite this article

Chang Yongxina , Li Baia , Gao Yunfana , Xu Kuoxi . A Novel Schiff-Base Fluorescent Probe for Cr3+ and Its Bioimaging in Cells[J]. Chinese Journal of Organic Chemistry, 2019 , 39(4) : 1023 -1028 . DOI: 10.6023/cjoc201809028

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