Chinese Journal of Organic Chemistry >
Solvent-Free Aldol Reaction of β-Porphyrin Formaldehyde with Ketone
Received date: 2018-10-05
Revised date: 2019-01-18
Online published: 2019-03-08
Supported by
Project supported by the Science and Technology Planning Project of Henan Province of China (No. 192102310141).
A convenient approach for the synthesis of β-substituted α,β-unsaturated carbonyl porphyrin compounds via base-catalyzed aldol reaction was developed. By this method, a series of β-substituted α,β-unsaturated carbonyl porphyrin compounds were constructed using β-porphyrin formaldehyde and ketones with moderate to excellent yields under mild reaction conditions, especially solvent-free, and good functional group tolerance. Furthermore, this process was successfully applied to the reactions of different metal porphyrin which have been reported to have poor reaction effects with good yields.
Key words： metal porphyrin; α,β-unsaturated carbonyl; aldol reaction; solvent-free
Zhou Xiang , Zhou Fei , Jia Xiaoliang , Yu Jiawei , Shen Qi , Zhang Yunxiao , Shi Weimin . Solvent-Free Aldol Reaction of β-Porphyrin Formaldehyde with Ketone[J]. Chinese Journal of Organic Chemistry, 2019 , 39(7) : 2084 -2088 . DOI: 10.6023/cjoc201810004
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