Chinese Journal of Organic Chemistry >
A Synthetic Route to Access Allyl-methyl-N-pantothenamide via [2,3]-Wittig Rearrangement
Received date: 2018-11-05
Revised date: 2019-01-17
Online published: 2019-03-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21372205, 21302175) and the Basic Research Project of Science and Technology Department of Henan Province (No. 132300410028).
The synthetic route of allyl-methyl-N-pantothenamide (1) featuring[2,3]-Wittig rearrangement and palladium catalyzed formate reduction to assemble the requisite quaternary carbon with adjacent secondary alcohol has been reported. Our strategy presents a facile synthetic route to access 1 in 10 steps, which also provide a novel inspiration to construct chiral quaternary carbon via asymmetrical[2,3]-Wittig rearrangement.
Xia Liwen , Zhao Qing , Ba Mengyu , Hu chaoping , Sun Moran , Yang Hua . A Synthetic Route to Access Allyl-methyl-N-pantothenamide via [2,3]-Wittig Rearrangement[J]. Chinese Journal of Organic Chemistry, 2019 , 39(7) : 2035 -2041 . DOI: 10.6023/cjoc201811009
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