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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 9: 2574 - 2580

DOI: https://doi.org/10.6023/cjoc201901016

ARTICLE

Synthesis and Anti-toxoplasma Activity in Vitro of Chrysin Derivatives

  • Shang Fanfan ,
  • Jin Lan ,
  • Zhang Haibin ,
  • Piao Lianxun ,
  • Quan Zheshan
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  • College of Pharmacy, Yanbian University, Yanji 133002

Received date: 2019-01-11

  Revised date: 2019-02-28

  Online published: 2019-03-21

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21662036, 81660344).

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Abstract

In this paper, 18 novel chrysin derivatives were designed and synthesized. All target compounds were tested for anti-Toxoplasma activity by methyl thiazolyl tetrazolium (MTT) colorimetric method. The chemical structures were characterized by 1H NMR, 13C NMR and HRMS spectra. The selectivity index of 5-hydroxy-7-methoxy-4-oxo-N,2-diphenyl-4H-chro-mene-8-sulfonamide (D2) was 1.76, indicating that the anti-toxoplasma activity of compound D2 was significantly higher than that of the lead compound chrysin and the positive control drug sulfadiazine.

Key words： chrysin derivatives; synthesis; toxoplasma activity; in vitro; selectivity index

Cite this article

Shang Fanfan , Jin Lan , Zhang Haibin , Piao Lianxun , Quan Zheshan . Synthesis and Anti-toxoplasma Activity in Vitro of Chrysin Derivatives[J]. Chinese Journal of Organic Chemistry, 2019 , 39(9) : 2574 -2580 . DOI: 10.6023/cjoc201901016

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