Chinese Journal of Organic Chemistry >
Progress in the Synthesis of Analogues of Bistetrahdro-isoquinoline Antitumor Alkaloids
Received date: 2018-10-30
Revised date: 2019-01-25
Online published: 2019-03-29
Supported by
Project supported by the Research Fund Project of Wuhan Institute of Technology (No. K201440), the Pilot Program of Scientific Research Project of Hubei Provincial Department of Education (No. B2016057), the Open Fund of Key Laboratory of New Reactor and Green Chemical Technology of Hubei Provincial (No. 201704).
Since the first tetrahydroisoquinoline alkaloid (THIQ), naphthyridinomycin, was found by Canadian scientist Kluepfel in 1974, nearly hundred members of this family have been reported. Such THIQ has attracted the research interest of many chemists and biologists due to its excellent biological activity and complex chemical structure. Especially, as an outstanding member of THIQ family, Ecteinascidin 743 (ET-743) has been commercialized in the European Union for the treatment of soft tissue tumors and ovarian cancer. Due to the extremely low content of natural products of bistetrahydroisoquinoline including ET-743 and the complexity of its chemical structure, the modification of its chemical structure has attracted more and more attention. Based on this, the recent advance in the synthesis of bistetrahydroisoquinoline analogues is reviewed.
Yang Yang , Guo Ju , Liu Zhanzhu . Progress in the Synthesis of Analogues of Bistetrahdro-isoquinoline Antitumor Alkaloids[J]. Chinese Journal of Organic Chemistry, 2019 , 39(7) : 1913 -1922 . DOI: 10.6023/cjoc201810037
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