Chinese Journal of Organic Chemistry >
One-Pot Synthesis of 2-((2-Aminobenzoyl)amino)benzoic Acid Derivatives
Received date: 2019-02-25
Revised date: 2019-04-17
Online published: 2019-05-10
Supported by
Project supported by the National Natural Science Foundation of China (No. 81773605), the Science and Technology Project of Sichuan Province (No. 2018JY0077), and the Interdisciplinary Frontier Basic Research Project of Southwest Jiaotong University (No. 2682017QY04).
An efficient and one-pot method for the preparation of 2-((2-aminobenzoyl)amino)benzoic acid derivatives has been reported. Twenty 2-((2-aminobenzoyl)amino)benzoic acid derivatives were prepared with 84%~99% yields and nine compounds are new compounds. The effects of electron effect and steric hindrance on the reaction were discussed. It provides an operationally simple, environmentally friendly, high yield and good substrate universality method for the synthesis of 2-(2-aminobenzamide)benzoic acid derivatives. Furthermore, macrolide 4 and quinazolinone 5 can be synthesized from 2-((2-ami-nobenzoyl)amino)benzoic acid (3a) in one-step over 92% yields.
Wan Linxi , Gao Feng , Chen Wei , Zhou Xianli . One-Pot Synthesis of 2-((2-Aminobenzoyl)amino)benzoic Acid Derivatives[J]. Chinese Journal of Organic Chemistry, 2019 , 39(8) : 2270 -2276 . DOI: 10.6023/cjoc201902029
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