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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 9: 2655 - 2662

DOI: https://doi.org/10.6023/cjoc201903056

NOTE

Synthesis and Insecticidal Activity of 3-Arylisoxazoline-pyrazole-5-carboxamide Derivatives

  • Zhong Liangkun ,
  • Jiang Tao ,
  • Zhang Fan ,
  • Fu Qing ,
  • Liu Xinghai ,
  • Xu Tianming ,
  • Ding Chengrong ,
  • Chen Jie ,
  • Yuan Jing ,
  • Tan Chengxia
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  • a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;
    a Zhejiang Research Institute of Chemical Industry. Ltd., Hangzhou 310023;
    b School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300

Received date: 2019-03-26

  Revised date: 2019-04-19

  Online published: 2019-05-15

Supported by

Project supported by the National Key Research and Development Plan (No. 2017YFD0200507).

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Abstract

A series of 3-arylisoxazoline-pyrazole-5-carboxamide derivatives derived from ethyl 5,5-dimethoxy-2,4-dioxopentanoate were designed, synthesized, and characterized by 1H NMR, 13C NMR and HRMS. The preliminary bioassay indicated that most title compounds exhibited positive potency against Mythimna separate (Walker) at 500 mg/L. At the concentration of 100 mg/L, three compounds were still moderately active against Mythimna separate (Walker) (lethal rate≈60%). At 500 mg/L, four compounds were also active against Aphis craccivora. The results indicated that the potential of these 3-arylisoxazoline-pyrazole-5-carboxamide derivatives can be utilized in insecticide research with further optimization.

Key words： arylisoxazoline; pyrazole-5-carboxamide; synthesis; insecticidal activity

Cite this article

Zhong Liangkun , Jiang Tao , Zhang Fan , Fu Qing , Liu Xinghai , Xu Tianming , Ding Chengrong , Chen Jie , Yuan Jing , Tan Chengxia . Synthesis and Insecticidal Activity of 3-Arylisoxazoline-pyrazole-5-carboxamide Derivatives[J]. Chinese Journal of Organic Chemistry, 2019 , 39(9) : 2655 -2662 . DOI: 10.6023/cjoc201903056

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