Chinese Journal of Organic Chemistry >
Research Progress of Phenazine-1-carboxylic Acid and Its Analogue
Received date: 2019-04-09
Revised date: 2019-05-16
Online published: 2019-06-03
Supported by
Project supported by the National Key R&D Program of China(2018YFD0200500);The National Natural Science Foundation of China(31672069);The Funds for Excellent Doctoral Dissertation Cultivation Program in Yangtze University
Phenazine-1-carboxylic acid (PCA) as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes, which displays potent inhibitory activities against plant pathogens, and has medical antibacterial and antitumor effects, and so on. In this review, the biosynthesis and chemosynthesis of phenazine-1-carboxylic acid are summarized. At the same time, the diverse biological evaluations of its biosynthetic and chemosynthetic analogues are summarized, which could provide reference for the study of structural modifications and biological activities of these analogues.
Key words： phenazine-1-carboxylic acid; analogues; research progress
Xiang Zhu , Qinglai Wu , Junkai Li . Research Progress of Phenazine-1-carboxylic Acid and Its Analogue[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2744 -2758 . DOI: 10.6023/cjoc201904023
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