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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 10: 2759 - 2770

DOI: https://doi.org/10.6023/cjoc201904055

REVIEW

Recent Progresses in the Synthesis of Solanoeclepin A

  • Mao Sun ,
  • Fayang Qiu ,
  • Wei-Dong Li
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  • a Pharmaceutical Laboratory, An Shun City People’s Hospital, Anshun 561000;
    b Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 40133
    c School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    d Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530

Received date: 2019-04-23

  Revised date: 2019-05-13

  Online published: 2019-06-03

Supported by

Project supported by the National Natural Science Foundation of China(21672030)

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Abstract

Solanoeclepin A, first isolated from potato roots (Solanaceae Juss.) by Mulder et al., is an highly active hatching stimulant (0.3 g per hectare) of potato cyst nematode (PCN, Globodera rostochiensis and G. pallida) which causes severe damage to potato crops. Its complex chemical structure belongs to a rearranged tetranortriterpene and possesses extremely unique skeleton. Based on the known general biosynthesis of tetranortriterpenoids and Prof. Corey’s biomimetic synthesis of glycinoeclepin, a plausible biosynthetic pathway of solanoeclepin A is proposed. A schematic review on the synthetic studies towards solanoeclepin A is provided.

Key words： solanoeclepin A; tetranortriterpene; natural product; total synthesis

Cite this article

Mao Sun , Fayang Qiu , Wei-Dong Li . Recent Progresses in the Synthesis of Solanoeclepin A[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2759 -2770 . DOI: 10.6023/cjoc201904055

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