Chinese Journal of Organic Chemistry >
Advances on the Synthesis of Aryl Ethers via Dehydrogenative Coupling
Received date: 2019-04-04
Revised date: 2019-05-09
Online published: 2019-06-06
Supported by
Project supported by the Natural Science Foundation of Zhejiang Province(LQ19B020002);The Municipal Natural Science Foundation of Ningbo City(2018A610241);The Education Foundation of Zhejiang Province(Y201839228);The K. C. Wong Magna Fund in Ningbo University
Aryl ethers are important central motifs that are abundant in many natural products and drug molecules, as well as versatile building blocks for organic synthesis. Aryl ethers were usually synthesized through the coupling reactions between leaving group substituted arenes and alcohols. However, the introduction of leaving group requires extra synthetic operation and produces lots of wastes. Over the past decade, the method for the synthesis of aryl ethers via C—H alkoxylation or aryloxylation has received much attention due to its potential as an atom and step efficient methodology. Herein, the research advances on the synthesis of aryl ethers through dehydrogenative coupling are reviewed. The detailed substrate scopes and reaction mechanisms, as well as the limitations of current procedures and the prospects for the future, are discussed.
Key words： aryl ether; dehydrogenative coupling; C—H activation; phenol; alcohol
Hao Tang , Junfei Luo , Pan Xie . Advances on the Synthesis of Aryl Ethers via Dehydrogenative Coupling[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2735 -2743 . DOI: 10.6023/cjoc201904011
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