Chinese Journal of Organic Chemistry >
Progress in the Synthesis of 1,2,4-Triazines by Tandem Cyclization
Received date: 2019-05-14
Revised date: 2019-06-03
Online published: 2019-06-24
Supported by
Project supported by the National Natural Science Foundation of China(21901124);The Jiangsu University Natural Science Research Program(19KJB150032);The China Postdoctoral Science Foundation(2019M651809);The Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTE1850);The Postdoctoral Science Foundation of Anhui Province(2018B252)
1,2,4-Triazine compounds are an important class of nitrogen-containing heterocyclic compounds. They have wide applications in the fields of medicine, chemicals and materials. Therefore, green and highly efficient synthesis of 1,2,4-triazine compounds is increasingly attracting the attention of researchers. By tandem cyclization reaction, the post-treatment of intermediate is avoided, and the one-pot synthesis of triazine compounds is the most efficient and direct synthesis method, which conforms to the concept of green chemistry for its step and atomic economy. The formation of C—N bond based on tandem cyclization to give 1,2,4-triazine compounds is reviewed. The synthetic method, reaction mechanism and application of 1,2,4-triazine compounds are introduced under transition-metal and metal-free conditions in the past ten years. The prospects of synthesis of triazine rings are also discussed.
Mingrui Li , Qifeng Ding , Boyang Li , Yang Yu , He Huang , Fei Huang . Progress in the Synthesis of 1,2,4-Triazines by Tandem Cyclization[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2713 -2725 . DOI: 10.6023/cjoc201905036
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