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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 11: 3183 - 3189

DOI: https://doi.org/10.6023/cjoc201904002

Synthesis of 3-Ethanoyl/Aroylacetylindoles in Water

  • Xiaoyu Hu ,
  • Haifeng Yu ,
  • Wenju Wang ,
  • Siao Jiang ,
  • Qi Liu ,
  • Jie He
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  • a College of Chemistry, Baicheng Normal University, Baicheng, Jilin 137000

Received date: 2019-04-03

  Online published: 2019-07-09

Supported by

the Foundation of Science and Technology Research Projects of the 13th Five-Year Plan of Jilin Provincial Department of Education(2016037)

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Abstract

4-Dodecylbenzenesulfonic acid (DBSA) catalyzed hydrolysis reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones (1) in water to yield 3-ethanoyl/aroylacetylindoles (2) was studied. It showed that the hydrolysis of 1 in water smoothly occurred in the presence of 10 mol% DBSA in reflux water, and 2 was obtained in excellent yield.

Key words： aqueous reaction; hydrolysis reaction; 3-acetoacetylindole; β-ethylthio-β-indolyl-α, β-unsaturated ketone

Cite this article

Xiaoyu Hu , Haifeng Yu , Wenju Wang , Siao Jiang , Qi Liu , Jie He . Synthesis of 3-Ethanoyl/Aroylacetylindoles in Water[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3183 -3189 . DOI: 10.6023/cjoc201904002

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