Chinese Journal of Organic Chemistry >
Progress in N-H Insertion Reaction of α-Diazocarbonyl Compounds
Received date: 2019-04-16
Online published: 2019-07-09
Supported by
the National Natural Science Foundation of China(21901124);the Jiangsu University Natural Science Research Program(19KJB150032);the China Postdoctoral Science Foundation(2019M651809);the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTE1850);the Anhui Province Postdoctoral Science Foundation(2018B252)
The α-diazocarbonyl compounds are easy to prepare and can be dediazonized to highly reactive carbene intermediates under thermolytic or photolytic conditions. Chemical bonds can be efficiently constructed by carbene mediated reactions, including the insertion reaction of carbene into N-H bonds which is an effective method for constructing C-N bonds. The α-diazocarbonyl compounds have received extensive application in organic synthesis and pharmaceutical synthesis. The research progress in the insertion reaction of α-diazocarbonyl compounds into N-H bonds under transition metal, organic small molecules, biomacromolecule or photolytic and thermolytic conditions is summarized, including the reaction mechanism and synthesis applications. Finally, the prospects of this reaction are also discussed.
Key words： α-diazocarbonyl compound; carbene; N-H insertion reaction; C-N bond
Jiajun Feng , Xiangyan Yi , Yaofeng Fu , Yang Yu , Fei Huang . Progress in N-H Insertion Reaction of α-Diazocarbonyl Compounds[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3013 -3025 . DOI: 10.6023/cjoc201904044
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