Chinese Journal of Organic Chemistry >
Eco-friendly C-3 Selenation of Imidazo[1,2-a]pyridines in Ionic Liquid
Received date: 2019-04-24
Revised date: 2019-06-12
Online published: 2019-07-09
Supported by
Project supported by the National Natural Science Foundation of China(21801007);The Program for Innovative Research Team of Science and Technology in the University of Henan Province(18IRTSTHN004);The Program for Innovative Research Team of Science and Technology in the University of Henan Province(18HASTIT006)
An relative eco-friendly protocol for the direct C-3 selenation of imidazo[1,2-a]pyridines with vorious organoselenides has been developed, gaving the desired products in moderate to excellent yields. Preliminary experimental results are consistent with a C-3 electrophilic functionalization mechanism. The features with relative green reaction conditions, broad substrate scope, and easy scale-up operation would make this strategy promising and important for the preparation of nitrogen and selenium containing molecules.
Xin Wang , Shiqiang Mu , Ting Sun , Kai Sun . Eco-friendly C-3 Selenation of Imidazo[1,2-a]pyridines in Ionic Liquid[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2802 -2807 . DOI: 10.6023/cjoc201904057
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