Chinese Journal of Organic Chemistry >
A Response Rate Matching Dual-Reactable Probe for Fluorescent Recognition of Hydrogen Sulfide
Received date: 2019-05-16
Online published: 2019-07-17
Supported by
the National Natural Science Foundation of China(21778013);the Natural Science Foundation of Hebei Province(B2018201234);the Colleges and Universities Science Technology Research Project of Hebei Province(QN2017015);the Science Technology Research and Development Guidance Programme Project of Baoding City(16zg031);the Open Fund of Laboratory in Hebei University(sy201833);the Open Fund of Laboratory in Hebei University(KYZJX18144)
A dual-reactable H2S fluorescent probe was designed and synthesized by employing ortho-fluoro-substituted coumarin azide and 7-nitrobenzofurazan-piperazine as the H2S reactive groups and the fluorescence quenching groups. The recognition behaviors of the probe to H2S were investigated and the results showed that the probe exhibited high selectivity and sensitivity. The fluorescence off-on enhancement was ca. 3600-fold, and the detection limit was 4.0×10-8 mol/L. The results of enzyme activity test indicated that the probe could be used for cystathionine β-synthase (CBS) activity detection and inhibitor screening. Furthermore, the probe was successfully applied for the imaging of H2S in living cells.
Key words： hydrogen sulfide; response rate; dual-reactable; fluorescent probe
Chang Xie , Chen Ma , Xu Jia , Xueqi Zhang , Chao Wei , Pingzhu Zhang , Xiaoliu Li . A Response Rate Matching Dual-Reactable Probe for Fluorescent Recognition of Hydrogen Sulfide[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3277 -3282 . DOI: 10.6023/cjoc201905038
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