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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 11: 3264 - 3268

DOI: https://doi.org/10.6023/cjoc201905010

Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities

  • Jiaocen Guo ,
  • Qingyun Ma ,
  • Fangdong Kong ,
  • Qingyi Xie ,
  • Liman Zhou ,
  • Qiong Ding ,
  • Yougen Wu ,
  • Youxing Zhao
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  • a College of Horticulture, Hainan University, Haikou 570228
    b Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101

Received date: 2019-05-07

  Online published: 2019-07-24

Supported by

the Natural Science Foundation of Hainan Province(219MS078);the Natural Science Foundation of Hainan Province(2019CXTD411);the China Agriculture Research System(CARS-21);the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(17CXTD-15);the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(1630052016008)

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Abstract

Three new meroterpenoids of ganoduriporols C~E were isolated from the fruiting bodies of Ganoderma ahmadii Steyaret by silica gel column, high performance liquid chromatography (HPLC) and other chromatography methods. Their structures were determined by spectroscopic techniques including NMR and HR-ESI-MS. Their inhibitory activities for protein tyrosine phosphatase 1B (PTP1B) in vitro were tested. The results showed that the three compounds had obvious PTP1B inhibitory activitiy with the IC50 values of 19.1, 17.81, and 29.6 μmol·L-1, respectively.

Key words： Ganoderma ahmadii Steyaret; meroterpenoid compound; PTP1B inhibitory effect

Cite this article

Jiaocen Guo , Qingyun Ma , Fangdong Kong , Qingyi Xie , Liman Zhou , Qiong Ding , Yougen Wu , Youxing Zhao . Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3264 -3268 . DOI: 10.6023/cjoc201905010

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