An “Off-On” Fluorescent Probe for Biothiols and Its Application in Bioimaging

  • Zhou Tingting ,
  • Yang Yutao ,
  • Zhou Keyan ,
  • Xu Wenzhi ,
  • Li Wei
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  • a College of Chemistry & Environmental Science, Hebei University, Baoding 071002;
    b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002

Received date: 2019-06-05

  Revised date: 2019-07-06

  Online published: 2019-08-01

Supported by

Project supported by the National Natural Science Foundation of China (No. 21807021), the Priority Strategy Project of Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education (No. ts2019004), the Science Foundation for Youth of Hebei Province (No. B2017201093) and the Hebei University Science Foundation for High-Level Personnel.

Abstract

An "off-on" fluorescent probe CO-NBS based coumarin derivative was designed and synthesized, which can respond selectively with biothiols including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH). The optical properties were studied by UV-Vis absorption spectrum and fluorescence spectrum. The results showed that probe was capable to respond rapidly, sensitively and selectively to Cys, Hcy and GSH with the detection limits of 92, 30 and 62 nmol/L, respectively. In addition, with low cytotoxicity and good biocompatibility, the probe can be successfully applied to image biothiols in living cells and in living zebrafish.

Cite this article

Zhou Tingting , Yang Yutao , Zhou Keyan , Xu Wenzhi , Li Wei . An “Off-On” Fluorescent Probe for Biothiols and Its Application in Bioimaging[J]. Chinese Journal of Organic Chemistry, 2019 , 39(12) : 3498 -3504 . DOI: 10.6023/cjoc201906004

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