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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 12: 3567 - 3573

DOI: https://doi.org/10.6023/cjoc201906012

Cesium-Catalyzed N-Carboxamidation of Indoles for Synthesis of Indole-1-carboxamides

  • Wu Yan ,
  • Wang Shan ,
  • Zhang Hailing ,
  • Chen Rui ,
  • He Shuhua
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  • Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Sichuan 408000

Received date: 2019-06-12

  Revised date: 2019-07-24

  Online published: 2019-08-07

Supported by

Project supported by the Basic and Frontier Research Project of Chongqing City (No. Cstc2018jcyjAX0721), the Youth Talent Growth Plan Project of Yangtze Normal University (No. 2018QNRC11), and the Education Commission of Chongqing City (No. KJQN201801404).

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Abstract

A protocol for the synthesis of a series of indole-1-carboxamides was reported via the N-arboxamidation of indole derivatives with aryl (alkyl) isocyanates catalyzed by 5.0 mol% cesium hydroxide monohydrate (CsOH·H2O). This method is suitable for different indole derivatives and aryl (alkyl) isocyanates, for giving corresponding products in excellent yields. Compared to the reported methods, this protocol has the advantages of mild reaction conditions, wild functional group tolerance, simple operation and excellent yields. An efficient route to indole-1-carboxamides is previded.

Key words： cesium-catalyzed N-arboxamidation; indole-1-carboxamides; indole derivatives; aryl (alkyl) isocyanates

Cite this article

Wu Yan , Wang Shan , Zhang Hailing , Chen Rui , He Shuhua . Cesium-Catalyzed N-Carboxamidation of Indoles for Synthesis of Indole-1-carboxamides[J]. Chinese Journal of Organic Chemistry, 2019 , 39(12) : 3567 -3573 . DOI: 10.6023/cjoc201906012

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