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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 10: 2936 - 2940

DOI: https://doi.org/10.6023/cjoc201907024

NOTES

Total Synthesis of Pulchrol and Pulchral

  • Dongdong Guo, ,
  • Wuxia Zhang, ,
  • Weimei Gao, ,
  • Xiaodi Guo, ,
  • Yongqiang Wang,
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  • a College of Arts and Sciences, Shanxi Agricultural University, Taigu 030801, Shanxi
    b Department of Chemistry &Materials Science, Northwest University, Xi'an 710069;

Received date: 2019-07-17

  Revised date: 2019-08-20

  Online published: 2019-09-05

Supported by

Project supported by the National Natural Science Foundation of China(31800678);the Science and Technology Research Project in ShanXi Province(201801D221062);the Science and Technology Research Project in ShanXi Province(201801D221063);the Shanxi Excellent Doctor Grant Award(SXYBKY201737);the Shanxi Excellent Doctor Grant Award(SXYBKY201706);the Science and Technology Innovation Project of Shanxi Agricultural University(Nos. 2017YJ38);the Science and Technology Innovation Project of Shanxi Agricultural University(2017YJ41)

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Abstract

The total synthesis of natural products pulchrol and pulchral with antiprotozoan activity was reported, starting from the cheap hydroquinone and 4-methylbenzoic acid and using palladium-catalyzed intramolecular decarboxylation coupling reaction of arene carboxylic acids with aryl bromides as the key reaction. This method provides an opportunity for further study of the structure-activity relationship.

Key words： natural product; total synthesis; cross-coupling; pulchrol; pulchral

Cite this article

Dongdong Guo, , Wuxia Zhang, , Weimei Gao, , Xiaodi Guo, , Yongqiang Wang, . Total Synthesis of Pulchrol and Pulchral[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2936 -2940 . DOI: 10.6023/cjoc201907024

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