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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 5: 1384 - 1387

DOI: https://doi.org/10.6023/cjoc201910003

Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives

  • Wu Yan ,
  • Tian Xianzhi ,
  • Zhang Hailing ,
  • Chen Rui ,
  • Cao Tuanwu
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  • Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408000

Received date: 2019-10-06

  Revised date: 2019-12-03

  Online published: 2020-01-03

Supported by

Project supported by the Basic and Frontier Research Project of Chongqing City (Nos. Cstc2018jcyjAX0721, Cstc2016jcyjA0056), the Youth Talent Growth Plan Project of Yangtze Normal University (No. 2018QNRC11), and the Education Commission of Chongqing City (No. KJQN201801404).

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Abstract

3-Selenocyanateindole derivatives have potential application in drug research due to their good biological activity. Until now, many methods for the synthesis of 3-selenocyanateindoles have been reported. However, drawbacks still exist, such as harsh reaction conditions, low yields and poor functional groups tolerance. A series of 3-selenocyanateindoles have been synthesized via the microwave-assisted 3-selenocyanation of indole derivatives by using 25 mol% iodine as catalyst, affording the corresponding products in good yields. Compared with the previous methods, this protocol has the advantages of rapid reaction, high yields and good atomic economy, providing an efficient route to 3-selenocyanateindole derivatives.

Key words： microwave-assisted reaction; iodine-catalyzed selenocyanation; 3-selenocyanate iodines; iodine derivatives; potassium selenocyanate

Cite this article

Wu Yan , Tian Xianzhi , Zhang Hailing , Chen Rui , Cao Tuanwu . Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives[J]. Chinese Journal of Organic Chemistry, 2020 , 40(5) : 1384 -1387 . DOI: 10.6023/cjoc201910003

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