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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 4: 817 - 830

DOI: https://doi.org/10.6023/cjoc201910029

Recent Advancement in Benzofulvene Synthesis

  • Shi Chuanxing ,
  • Feng Chenguo ,
  • Chen Yali ,
  • Zhang Shusheng ,
  • Lin Guoqiang
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  • a College of Sciences, Shanghai University, Shanghai 200444;
    b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c Innovation Research Instutute of Tranditional Chinese Medicine, Shanghai University of Tranditional Chinese Medicine, Shanghai 201203

Received date: 2019-10-25

  Revised date: 2019-12-17

  Online published: 2020-01-03

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21572253, 21772216), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB 20020100), and the Key Research Program of Frontier Science (No. QYZDY-SSWSLH026).

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Abstract

Benzofulvenes were widely found in natural products and bioactive molecules, and also served as important building blocks in material science and transition-metal chemistry. Great efforts have been devoted to the efficient synthesis of these interesting molecules, and rapid advancement has been made in the past two decades. According to the types of the initiation of the reaction, these methods can roughly be classified into five categories:thermal or photochemical cyclization of enyne-al-lenes or enediynes, transition metal-catalyzed sequential cyclization reaction, electrophilic or nucleophilic attack initiated cyclization, radical initiated cyclization and acid promoted cyclization. This review describes the important synthetic methods of benzofulvenes according to their reaction types.

Key words： benzofulvenes; transition metal catalysis; radical; C—H bond activation; cyclization reaction

Cite this article

Shi Chuanxing , Feng Chenguo , Chen Yali , Zhang Shusheng , Lin Guoqiang . Recent Advancement in Benzofulvene Synthesis[J]. Chinese Journal of Organic Chemistry, 2020 , 40(4) : 817 -830 . DOI: 10.6023/cjoc201910029

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