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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 5: 1367 - 1371

DOI: https://doi.org/10.6023/cjoc201912012

Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum FS521

  • Zhang Jie ,
  • Chen Yuchan ,
  • Liu Zhaoming ,
  • Guo Bohong ,
  • Gao Xiaoxia ,
  • Liu Hongxin ,
  • Zhang Weimin
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  • a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070;
    b School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006

Received date: 2019-12-09

  Revised date: 2020-01-05

  Online published: 2020-01-15

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 41906106, 31272087), the Pearl River Science and Technology New Star Fund of Guangzhou Province (No. 201806010080), the Team Project of the Natural Science Foundation of Guangdong Province (No. 2016A030312014), and the Project of Science and Technology Development of Guangdong Academy of Sciences (No. 2019GDASYL-0103007).

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Abstract

One new compound, named hypoxone A (1), together with two new natural products 4,8-dimethoxy-1-naphthol (2) and 1'-hydroxy-4',8,8'-trimethoxy[2,2']binaphthalenyl-1,4-dione (3), and fourteen known derivatives 4~17 were isolated from the broth extract of the marine fungus Hypoxylon rubiginosum FS521, which was isolated from a deep-sea sediment sample. Their structures were elucidated by interpretation of spectroscopic analysis and comparison with previously published data for the known ones. Moreover, compounds 1~4 were evaluated for their in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines, and compound 3 exhibited potent cytotoxic activity with IC50 values of 1.85, 3.21, 2.53, and 5.09 mmol·L-1, respectively.

Key words： marine fungus; Hypoxylon rubiginosum; cytotoxicity; polyketides

Cite this article

Zhang Jie , Chen Yuchan , Liu Zhaoming , Guo Bohong , Gao Xiaoxia , Liu Hongxin , Zhang Weimin . Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum FS521[J]. Chinese Journal of Organic Chemistry, 2020 , 40(5) : 1367 -1371 . DOI: 10.6023/cjoc201912012

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