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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 5: 1087 - 1095

DOI: https://doi.org/10.6023/cjoc202002017

ACCOUNT

Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes

  • Zhang Wenwen ,
  • Wang Zixuan ,
  • Bai Xiaoyan ,
  • Li Bijie
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  • Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084

Received date: 2020-02-16

  Revised date: 2020-03-08

  Online published: 2020-03-31

Supported by

Project supported by the Thousand Young Talents Program.

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Abstract

Catalytic asymmetric hydrofunctionalization of alkene is an important research field, which enables efficient construction of chiral molecules from readily available starting materials. Asymmetric hydrofunctionalization of multiple substituted alkenes represents a significant challenge to organic chemists because this process involves the simutaneous control of regio-, diastereo-, and enantio-selectivities. The key to solve this challenge is to identify novel catalyst systems to exert powerful regio- and stereo-control. Recently, by taking advantage of substrate-directed strategy, we have developed a number of alkene functionalization methods with excellent regio-, diastereo-, and enantio-selectivities. In particular, we focus on catalytic asymmetric hydroalkynylation of alkenes as a model transformation to analyze the factors that control the selectivity.

Key words： alkene functionalization; asymmetric catalysis; selectivity; substrate-directed strategy; transition metal catalysis

Cite this article

Zhang Wenwen , Wang Zixuan , Bai Xiaoyan , Li Bijie . Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes[J]. Chinese Journal of Organic Chemistry, 2020 , 40(5) : 1087 -1095 . DOI: 10.6023/cjoc202002017

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