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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 7: 2108 - 2113

DOI: https://doi.org/10.6023/cjoc202003026

Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles

  • Li Qianqian ,
  • Wu Zhongmei ,
  • Zhang Min ,
  • Zhang Yiping ,
  • Zhou Yingkai ,
  • Deng Hongmei ,
  • Song Liping
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  • a Department of Chemistry, College of Science, Shanghai University, Shanghai 200444;
    b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c Laboratory for Microstructures, Shanghai University, Shanghai 200444

Received date: 2020-03-10

  Revised date: 2020-04-09

  Online published: 2020-05-08

Supported by

Project supported by the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

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Abstract

The synthesis of isoxazole derivatives has been paid much attention by organic synthetic chemists because isoxazoles usually exhibit good biological activity such as insecticidal and bactericidal activity. In this study, a series of 3-aryl-4-arylamine methyl isoxazole derivatives were synthesized from ethyl 3-arylisoxazole-4-carboxylate by reduction, bromination and substitution reaction. The synthesized compounds were identified by 1H NMR, 13C NMR and HRMS, and the preliminary bioactivity test results showed that some compounds obtained had good inhibitory effects anainst aphids and armyworms.

Key words： isoxazole derivative; synthesis; arylamine methyl group; biological activity

Cite this article

Li Qianqian , Wu Zhongmei , Zhang Min , Zhang Yiping , Zhou Yingkai , Deng Hongmei , Song Liping . Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles[J]. Chinese Journal of Organic Chemistry, 2020 , 40(7) : 2108 -2113 . DOI: 10.6023/cjoc202003026

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