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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 8: 2570 - 2574

DOI: https://doi.org/10.6023/cjoc202003044

Polyaniline-Supported Copper-Catalyzed Buchwald-Hartwig Couplings of Pyrimidin-2-amines

  • Chen Ying ,
  • Jing Xiaobi ,
  • Yu Lei
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  • School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002

Received date: 2020-03-17

  Revised date: 2020-05-01

  Online published: 2020-05-19

Supported by

Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20181449), the Jiangsu Provincial Six Talent Peaks Project (No. XCL-090) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Abstract

Buchwald-Hartwig couplings can modify the pyrimidin-2-amines. Since the pyrimidin-2-amine structures widely exist in medicines, the reaction is of significant industrial application values. The polyaniline-supported copper catalyst (Cu@PANI) was synthesized via the oxidative polymerization of aniline in the presence of copper salt and it could catalyze the Buchwald-Hartwig couplings of pyrimidin-2-amines. Since the nitrogen in polyaniline could well coordinate with copper, the reaction did not require additional ligands and occurred at relatively high catalyst turnover numbers (TONs). As a heterogeneous catalyst, Cu@PANI could be recycled and reused to reduce the cost of catalyst, and meet the requirements of industrial application.

Key words： polyaniline; copper; catalysis; Buchwald-Hartwig coupling; ligand-free

Cite this article

Chen Ying , Jing Xiaobi , Yu Lei . Polyaniline-Supported Copper-Catalyzed Buchwald-Hartwig Couplings of Pyrimidin-2-amines[J]. Chinese Journal of Organic Chemistry, 2020 , 40(8) : 2570 -2574 . DOI: 10.6023/cjoc202003044

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