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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 8: 2290 - 2307

DOI: https://doi.org/10.6023/cjoc202004024

Recent Progress in Radical Alkylation of Heteroarenes Based on C(sp3)-H bond Cleavage Strategy

  • Luo Wenkun ,
  • Yang Kai ,
  • Yin Biaolin
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  • a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640;
    b College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000

Received date: 2020-04-14

  Revised date: 2020-05-09

  Online published: 2020-05-19

Supported by

Project supported by the National Natural Science Foundation of China (No. 21871094) and the Scientific Research Project of Gannan Medical University (No. YB201903).

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Abstract

Heteroarenes are widely found in synthetic drugs and natural products and exhibit various biological activities. Among them, alkylated heteroarenes play a crucial role in the pharmaceutical industry, and have attracted great attention of synthetic chemists. C(sp3)-H bond cleavage strategy was widely used in radical alkylation of heteroarenes in organic synthesis and has been successfully applied in the total synthesis of natural products and pharmaceuticals due to its excellent atom economy. Based on the different precursor compounds (ethers, alcohols, amines, esters, amides and common alkanes), the research progress of radical alkylation of heteroarenes in a decade is summarized, and the related mechanism is also discussed.

Key words： C-H cleavage; heteroarene; radical; alkylation

Cite this article

Luo Wenkun , Yang Kai , Yin Biaolin . Recent Progress in Radical Alkylation of Heteroarenes Based on C(sp3)-H bond Cleavage Strategy[J]. Chinese Journal of Organic Chemistry, 2020 , 40(8) : 2290 -2307 . DOI: 10.6023/cjoc202004024

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