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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 9: 2827 - 2835

DOI: https://doi.org/10.6023/cjoc202006006

New Use of Non-natural Catalytic Activity of Pepsin: Highly Efficient Synthesis of Tetrahydroquinazolines

  • Jiang Guofang ,
  • Lu Yue ,
  • Li Hongxia ,
  • Hu Zhiyu ,
  • Zhu Xiao ,
  • Xie Zongbo ,
  • Le Zhanggao
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  • Jiangxi Province Key Laboratory of Synthetic Chemistry, School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang, Jiangxi 330013

Received date: 2020-06-05

  Revised date: 2020-06-12

  Online published: 2020-06-28

Supported by

Project supported by the National Natural Science Foundation of China (No. 21462001), and the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006).

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Abstract

Pepsin from porcine gastric mucosa has a non-natural ability to catalyze the cyclocondensation of aromatic amines and 2-aminobenzaldehyde. The corresponding tetrahydroquinazolines were obtained in good yields (41%~95%) in aqueous methanol solution. The catalytic activity of pepsin was evaluated by investigating solvent, temperature, enzyme loading, and substrate ratio in the enzyme-catalyzed reaction. Herein, a potential biocatalytic approach as an alternative to chemical synthesis for tetrahydroquinazoline derivatives was proposed.

Key words： pepsin; non-natural catalytic activity; tetrahydroquinazoline; biocatalysis

Cite this article

Jiang Guofang , Lu Yue , Li Hongxia , Hu Zhiyu , Zhu Xiao , Xie Zongbo , Le Zhanggao . New Use of Non-natural Catalytic Activity of Pepsin: Highly Efficient Synthesis of Tetrahydroquinazolines[J]. Chinese Journal of Organic Chemistry, 2020 , 40(9) : 2827 -2835 . DOI: 10.6023/cjoc202006006

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