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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 10: 3120 - 3131

DOI: https://doi.org/10.6023/cjoc202005071

Progress in Structural Modification of Bicyclic Thiopeptide Antibiotics Based on Biosynthesis

  • Zhang E ,
  • Chen Dandan ,
  • Wang Shoufeng ,
  • Liu Wen
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  • a Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022;
    b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c Huzhou Center of Bio-Synthetic Innovation, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Huzhou, Zhejiang 313000

Received date: 2020-05-26

  Revised date: 2020-06-20

  Online published: 2020-07-09

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 31972850, 21750004, 21520102004), the Shandong Key Research Program (No. 2019GSF108223), the Chinese Academy of Sciences (Nos. QYZDJ-SSW-SLH037, XDB20020200), the Science and Technology Commission of Shanghai Municipality (No. 17JC1405100), the Youth Innovation Promotion Association of the Chinese Academy of Sciences (No. 2017303), and the K. C. Wong Education Foundation.

Fold

Abstract

Thiopeptide antibiotics are a class of natural products with polythiophene (oxazol) polypeptides, which are rich in sulfur and highly modified. They are produced by secondary metabolism of microorganisms and have good biological activities. Developing thiopeptides into clinic is currently a challenge partly due to their low aqueous solubility and associated poor bioavailability. On the basis of understanding the mechanism of their biosynthesis, the method of obtaining thiopeptide analogues via reasonable bioengineering has become the research focus of biologists. In this paper, the advances in structural modifications of bicyclic thiopeptides by taking thiostrepton and nosiheptide as representatives are reviewed.

Key words： biosynthesis; thiostrepton; nosiheptide; structural modifications

Cite this article

Zhang E , Chen Dandan , Wang Shoufeng , Liu Wen . Progress in Structural Modification of Bicyclic Thiopeptide Antibiotics Based on Biosynthesis[J]. Chinese Journal of Organic Chemistry, 2020 , 40(10) : 3120 -3131 . DOI: 10.6023/cjoc202005071

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