Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions

  • Ding Yuxin ,
  • Ma Yongmin ,
  • Chen Jing
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  • a School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053;
    b School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 318000

Received date: 2020-05-28

  Revised date: 2020-06-28

  Online published: 2020-07-23

Supported by

Project supported by the Natural Science Foundation of Zhejiang Province (No. LY19H300001), the Zhejiang Chinese Medicinal University Foundation (No. 2018ZG31) and the "Teacher Professional Development Project" for Domestic Visitors of Institutions of Higher Learning in 2019 (No. FX2019020).

Abstract

2,4,6-Triarylpyrimidines were synthesized via a simple, efficient, one-pot, three-component reaction from 1,3-dikeones, benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields. This "green" methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.

Cite this article

Ding Yuxin , Ma Yongmin , Chen Jing . Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2020 , 40(12) : 4357 -4363 . DOI: 10.6023/cjoc202005078

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