Base-Promoted Rapid Hydrosilylation of Aldimine

  • Wang Zichao ,
  • Xu Youjun ,
  • Shi Shiliang
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  • a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032;
    b Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, Shenyang 110016

Received date: 2020-05-29

  Revised date: 2020-07-03

  Online published: 2020-07-23

Supported by

Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000) and the National Natural Science Foundation of China (Nos. 21690074, 21871288, 91856111, 21821002).

Abstract

Amines are important intermediates in organic synthesis. The hydrosilylation of imines provides a convenient method for the synthesis of amines. Transition metal and main group catalysts have been widely applied in the hydrosilylation of imines. However, it would be more practical to use simpler reaction conditions to realize such reactions. In this paper, a fast hydrosilylation of aldimine was realized by using cheap t-BuOK as the promoter, providing an efficient method for the synthesis of amines in high yield. This reaction features rapid reaction, facile conditions, and robust practicability.

Cite this article

Wang Zichao , Xu Youjun , Shi Shiliang . Base-Promoted Rapid Hydrosilylation of Aldimine[J]. Chinese Journal of Organic Chemistry, 2020 , 40(10) : 3463 -3466 . DOI: 10.6023/cjoc202005085

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