Chinese Journal of Organic Chemistry >
Recent Progress in Fluorescent Probes for the Detection of Ferrous Ion
Received date: 2020-06-02
Revised date: 2020-07-10
Online published: 2020-08-01
Supported by
the Youth Science Foundation of Shanxi Province(201901D211348); the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(2019L0409); the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(2019L0444); the Ph. D Startup Fund of Shanxi Medical University(BS03201609)
Irons, as the most abundant transition metal in living system, play an irreplaceable role in many physiological and pathological processes. The misregulation of Fe 2+ homeostasis not only affects the occurence and delelopment of various diseases, such as cancer, cardiovascular disease and neurodegenerative disorders, but also induces ferroptosis. Although two forms of iron (Fe 2+ and Fe 3+) exist in cells, reducing microenvironment of cells makes it exist mainly in the form of Fe 2+. Therefore, developing a sensitive approach for Fe 2+ is particularly important because it may contribute to the in-depth understanding of the relationship between Fe 2+ and human health and disease. In recent years, with the rapid development of fluorescent imaging technique, fluorescent probes for the sensitive detection of Fe 2+ have attracted great interest. Fe 2+ fluorescent probes reported in the last ten years are summarized, according to probes design, sensing mechanisms with Fe 2+, optical properties and biological application. In addition, the development prospect of Fe 2+ fluorescent probes is predicted.
Key words： s ferrous ion; fluorescent probe; fluorescent imaging
Sufang Ma , Qiang Yu , Li Lu , Lihong Li , Wen Liu , Zhifang Wu , Sijin Li . Recent Progress in Fluorescent Probes for the Detection of Ferrous Ion[J]. Chinese Journal of Organic Chemistry, 2021 , 41(1) : 229 -240 . DOI: 10.6023/cjoc202006003
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