Chinese Journal of Organic Chemistry >
Convenient Method for Preparingα-Ketoarylthioamide by Air Oxidation under Base Conditions
Received date: 2020-06-04
Revised date: 2020-07-30
Online published: 2020-08-19
Supported by
the National Natural Science Foundation of China(81560559); the National Natural Science Foundation of China(81703356); the Natural Science Research Fund of Guizhou Education Department(黔教合KY字[2021]161); the Scientific and Technological Foundation of Guizhou Health Committee(gzwjk2019-1-179); the Mobile Postdoctoral Center of Guizhou Medical University
A practical method for preparing α-ketoaryl thioamide by air oxidation has been developed. Under air atmosphere, in the presence of K2CO3 as base and dimethyl sulfoxide (DMSO) as solvent at 120 ℃, a variety of α-ketoarylthioamides were obtained from aryl thioamide in yields of 42%~85%. This reaction has good substrate applicability, metal-free and atomic economy, and provides an efficient, economical, green and convenient method for the synthesis of α-ketoaryl thioamide.
Key words： air; dimethyl sulfoxide (DMSO); K2CO3; green oxidation; α-ketoaryl thioamide
Cong Wang , Yaoyao Yao , Jun Xie , Jianta Wang , Feiqing Wang , Jiquan Zhang , Lei Tang . Convenient Method for Preparingα-Ketoarylthioamide by Air Oxidation under Base Conditions[J]. Chinese Journal of Organic Chemistry, 2021 , 41(1) : 370 -375 . DOI: 10.6023/cjoc202002011
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